+1 249-493-6904
Volume 3 Issue 1
Consequences of Blood Loss in Cardiothoracic Surgery
Efforts to minimize perioperative blood loss in surgery in order to improve short and long- term outcome should be made, as implications extend considerably beyond the perioperative period. Minimally invasive approaches are associated with less bleeding. [..] READ MORE
A Novel Bioinformatic Approach for Large Deletion Detection in Multiplex Pcr-Based Ngs Assays
Background
Next-generation sequencing (NGS) has changed genetic diagnostics due to its high throughput, speed, and cost-effectiveness. This paper describes the challenges that were faced in detection of the frameshift variant c.1175_1214del in the BRCA1 gene, undetectable by CNV analysis, using Oncomine BRCA Research Assay (OBRA) and Ion Torrent platform. [..] READ MORE
Immunotherapy in Colorectal Cancer: A Promising Avenue?
Advancements in immunotherapy, particularly immune checkpoint inhibitors, have revolutionized the treatment of metastatic colorectal cancer (mCRC). However, the efficacy of available immunotherapeutic agents is largely limited to tumors with DNA mismatch repair-deficient (dMMR) and/or those with microsatellite instability-high (MSI-H) mCRC. [..] READ MORE
When Ribosomal Protein Go Bad-Mutation of Ribosomal Protein RPS23 in Different Diseases
Ribosomal protein (RP) gene mutations, mostly are associated with inherited or acquired bone marrow failure; it is believed that RP to drive disease by slowing the rate of protein synthesis. Ribosomes, are responsible for protein synthesis; ribosome, consist of a small 40S subunit and a large 60S subunit. [..] READ MORE
COVID-19 and the Severity of the Disease in Different Types of Cancer
Italy, Spain and the USA suffered the most in the early stages of the world wide outbreak of COVID-19 and subsequently the World Health Organization (WHO) declared the COVID-19 outbreak a global pandemic on 12 March 2020. Cancer patients with comorbidities (hypertension, diabetes and cardiorenovascular diseases) can lead to severe illness and death as cancer patients have a higher risk of severe illness and death than COVID-19 patients without cancer. [..] READ MORE
Visualization of an Intra-Operative X-Ray Source With Liquid Scintillation Imaging
Intraoperative radiotherapy (IORT) is an alternative to full course radiotherapy for select patients. The IntraBeam (Zeiss, Germany) delivery system uses a low energy (50kVp) x-ray source. In this communication, a method for rapidly characterizing emissions from an IORT x-ray source is shared. A leaded glass phantom was filled with liquid scintillation cocktail (LSC) (Ultima Gold; PerkinElmer, USA) and a 13 MP CMOS detector used to collect images and videos. [..] READ MORE
Total Articles Published
8
9
2
