Volume 3  Issue 1

Consequences of Blood Loss in Cardiothoracic Surgery

Massimo Baudo1*, Mohamed Rahouma2*, Mahmoud Morsi3, Yongle Ruan4, Sherif Khairallah2, Mohamed Kamel2, Galal Ghaly2, Ali Cheriat, N.5, Mohamed Hossny6, Omnia Mohamed7 & Abdelrahman Mohamed2

Efforts to minimize perioperative blood loss in surgery in order to improve short and long- term outcome should be made, as implications extend considerably beyond the perioperative period. Minimally invasive approaches are associated with less bleeding. [...] READ MORE

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A Novel Bioinformatic Approach for Large Deletion Detection in Multiplex Pcr-Based Ngs Assays

Fatemeh Abbaszadeh*, Shaza Abu Sirriya, Bincy Mathew, Ramin Badii, Vasiliki Chini, Zafar Nawaz & Susanna Akiki

Next-generation sequencing (NGS) has changed genetic diagnostics due to its high throughput, speed, and cost-effectiveness. This paper describes the challenges that were faced in detection of the frameshift variant c.1175_1214del in the BRCA1 gene, undetectable by CNV analysis, using Oncomine BRCA Research Assay (OBRA) and Ion Torrent platform. [...] READ MORE

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Immunotherapy in Colorectal Cancer: A Promising Avenue?

Danielle Hebert BS#, Kayla Flewelling BS#, Najiha Farooqi MD & Mohamed Kamel, K. MD*

Advancements in immunotherapy, particularly immune checkpoint inhibitors, have revolutionized the treatment of metastatic colorectal cancer (mCRC). However, the efficacy of available immunotherapeutic agents is largely limited to tumors with DNA mismatch repair-deficient (dMMR) and/or those with microsatellite instability-high (MSI-H) mCRC. [...] READ MORE

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When Ribosomal Protein Go Bad-Mutation of Ribosomal Protein RPS23 in Different Diseases

Shefki Xharra1#, Emir Behluli2#, Hilada Nefic3, Rifat Hadziselimovic3, Kumrije Sopi-Xharra1 & Gazmend Temaj4#*

Ribosomal protein (RP) gene mutations, mostly are associated with inherited or acquired bone marrow failure; it is believed that RP to drive disease by slowing the rate of protein synthesis. Ribosomes, are responsible for protein synthesis; ribosome, consist of a small 40S subunit and a large 60S subunit. [...] READ MORE

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