When Ribosomal Protein Go Bad-Mutation of Ribosomal Protein RPS23 in Different Diseases

Shefki Xharra1#, Emir Behluli2#, Hilada Nefic3, Rifat Hadziselimovic3, Kumrije Sopi-Xharra1 & Gazmend Temaj4#*

1Regional Hospital- Prizren, Sheh Emin, Prizren, Kosovo
2University of Prishtina Medical Faculty, Prishtina Kosovo
3Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
4College UBT Faculty of Pharmacy and Medicine, Kalabria nn, Prishtina, Kosovo

Dr. Gazmend Temaj, College UBT Faculty of Pharmacy and Medicine, Kalabria nn, Prishtina, Kosovo.

Keywords: RPS23; Cancer Diseases; Gene Stability


Ribosomal protein (RP) gene mutations, mostly are associated with inherited or acquired bone marrow failure; it is believed that RP to drive disease by slowing the rate of protein synthesis. Ribosomes, are responsible for protein synthesis; ribosome, consist of a small 40S subunit and a large 60S subunit. These subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Size of RPL23 is 143 amino acids, and molecular mass of this protein is 1508 Da. The gene for encoding this protein is placed in chromosome 5q14.2 by HGNC, Entrez Gene and Ensemble. It is shown that PRS23 is responsible for development and many cancer diseases.

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