The Microbiome, Stroke and Neurodegeneration
Department of Biological Chemistry, Ariel University, Ariel, Israel
Dr. Shatzmiller Shimon, Department of Biological Chemistry, Ariel University, Ariel, Israel.
Keywords: Microbiome; Dysbiosis; Macrobiotics
Significant dysbiosis occurs in the bowel microbiology of stroke patients. The thickening of these extensive and complex changes in one index will significantly help the clinical use of microbial data in the gut. Scientists developed a microbiota in the intestines in patients with acute ischemic stroke based on microbial colon patterns, and tested whether the index was correlated with brain injury and early outcome .
Dysbiosis of the gut microbiota has recently been essential for the development of a variety of chronic inflammatory diseases, such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease. Bacteria make phosphatidylcholine and l-carnitine from nutrients to trimethylamine, which is absorbed and further oxygenated by the hepatic flavin monooxygenase to trimethylamine-N-oxide (TMAO) , a metabolite that can promote partial atherogenesis by promoting the formation of foam cells Macrophages. The blood TMAO  level was reported to be positively associated with the risk of long-term mortality in patients with atherosclerosis, heart failure, and chronic kidney disease. In addition to the trimethylamine route, metagenomic research has suggested that symptomatic atherosclerosis is associated with altered bowel microbial 8. These results suggest potentially essential roles for gut microbiota in cardio and cerebrovascular diseases including transient ischemic stroke attack (Trans Ischemic Attack, (TIA). Such an attack is often called a mini- stroke, but it is really a great warning. TIA is a temporary blockage of blood flow to the brain. Since it does not cause permanent damage, it is often ignored. But that's a big mistake. TIAs may indicate a full stroke forward ? When you first notice the symptoms, get immediate help. See a detailed illustration of TIA. However, these diseases have rarely been tested relative to the TMAO level and microbiota in the intestines.
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