Preferential Eradication of Gram-Negative Bacteria Using Peptide Surrogates

Shimon Shatzmiller^*, Ludmila Buzhansky, Rami Krieger, Inbal Lapidot, Galina Zats, M. & Marina Kovaliov

Department of Chemical Sciences, Ariel University, Ariel Israel

Shimon Shatzmiller, Department of Chemical Sciences, Ariel University, Ariel Israel.

Keywords: Antibacterial; Drug Discovery; Microbe; Antibiotics; Antimicrobial Drugs

Abstract

Short surrogates of the pentapeptide K-A-A-A-K, centered on Freidinger’s lactam, were applied in the eradication of E. Coli (Gram-negative bacteria) and S. Aureus (Gram-positive microbe). It was found that it was easier to eradicate the gram-positive bacteria, and the eradication was influenced by the N-methylation of the amide nitrogen of 30g31 (table). However, The N-methylated surrogates were more efficient in the eradication of the E. Coli than the S. Aureus samples. We were able (Fig. 14) to show that one structural change could make a remarkable difference in the eradication (MIC) of the different bacteria.

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