Post-Infection and Postoperative Alzheimer’s Disease with Psychosis

Carlo Lazzari1*, Thimmaiah Rajanna1, Abdul Nusair1 & Marco Rabottini2

1Department of Psychiatry, Fieldhead Hospital, Ouchthorpe Lane, Wakefield, United Kingdom
2Centre for Neurosciences, International Centre for Healthcare and Medical Education, Bristol, United Kingdom

Dr. Carlo Lazzari, Department of Psychiatry, Fieldhead Hospital, Ouchthorpe Lane, Wakefield, United Kingdom.

Keywords: Neuroinflammation; Alzheimer’s Disease; Lipopolysaccaride; Lysosome; Surgery; Psychosis


The authors of the current article report on recent studies about the thinkable contribution of generalized sepsis and postoperative complications as hypothetical causes of Alzheimer Disease (AD) and psychosis in a vulnerable population. Author’s hypotheses have been supported by a clinical case in their clinic that developed AD and psychosis after generalized sepsis and a major surgical operation.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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