Possibility of NRF2 Activation as a Priming Tool Against SARS-COV-2 Infection

Morshedul Alam

Department of Genetic Engineering & Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh

Dr. Morshedul Alam, Department of Genetic Engineering & Biotechnology, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh.

Keywords: SARS-COV-2; Host Immune System; Inflammasome Inhibition

Abstract

The novel corona virus SARS-COV-2 outbreak has interrupted the social and global life. During the last century, several human coronaviruses have emerged, causing severe respiratory illness in humans, but the outbreaks were not so devastating. Coronaviruses (CoVs) are a large group of single-stranded RNA viruses belonging to the Coronaviridae family. The world experienced coronavirus for the first time in 2002-2003 by Severe Acute Respiratory Syndrome (SARS) and in 2011 by Middle East Respiratory Syndrome (MERS) and the fatality rate were about 10% and 34% respectively [1], but the biggest concern is that the current SARS-COV-2 outbreak rate already exceeded the previous two terms. The real fact is that though the previous two outbreaks were controlled in a felicitous way, but the present one is still out of control due to lack of appropriate knowledge of its pathogenesis and therapy. Scientists all over the world are trying to get an effective remedy by focusing on vaccine formulation and drug therapy, but a big concern is the efficacy with less side effects and selectivity.

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