Application of Nisin in Food and Pharmaceutical Industries

Fariba Goudarzi^1*, Robab Hassanvad Jamadi¹, Faraham Ahmadzadeh² & Hashem Yaghoubi³

¹Department of Biology, University of Mohaghegh Ardabili, Iran
²Department of Biodiversity and Ecosystem Management, Environmental Sciences Research Institute, Shahid Beheshti University, Iran
³Department of biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran

Fariba Goudarzi, Department of Biology, University of Mohaghegh Ardabili, Iran.

Keywords: Nisin; Food and Pharmaceutical Industries; Staphylococcus Aureus; Gastric Cancer Cell

Abstract

In the present study, the potential of the antimicrobial peptide of nisin has been studied in the food (antibacterial activity) and pharmaceutical (anticancer activity) industries. This peptide can be used both as a preservative and as a drug because the formation of pore in the membrane of bacteria. In this study, the antimicrobial activity of nisin on reference strain of Staphylococcus aureus ATCC 2592, a food pathogen, and the effect of this peptide on the gastric cancer cell line (AGS) has been investigated. The effect of nisin on Staphylococcus aureus ATCC 2592 was studied by the MIC method and it was observed that nisin has an antibacterial effect on this bacterial strain. Study on cytotoxicity effect of nisin in different concentrations on the gastric cancer cell line showed that with increased concentration and treatment time, more cytotoxicity was observed.

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