Criteria and Decision Limits of cTnI Sensitivity Respect to Coronary Stenosis in Patients with Non ST-Elevation Myocardial Infarction

Agustín Joison^1* & Baiardi Gustavo²

¹Department of Biological Chemistry, Córdoba Catholic University, Argentina
²Institute of Biological and Technological Research (IIBYT-CONICET), National University of Córdoba, Argentina

Dr. Agustín Joison, Department of Biological Chemistry, Córdoba Catholic University, Argentina.

Keywords: Cardiac Troponin I; Ischemia; Coronary Stenosis; Thrombosis

Abstract

unstable angina, acute myocardial infarction. These terms are called acute coronary syndrome. Concerning the same it is classified according to the electrocardiogram in ST-elevation myocardial infarction and non STelevation. Cardiac troponin-I as cardiac biomarker allows the myocardial injury in patients and values of serum cTn-I are measured join coronary angiography, at respect the increase in that biomarker is associated to extent of damage and severity of coronary arteries.
Materials and Methods
A descriptive, observational, and random study in 219 patients with non ST-elevation myocardial infarction was develop between 2014 and 2016 in the coronary unit of the “Reina Fabiola” Clinic, Córdoba, Argentina. Cardiac troponin I testing was measured baseline in emergency room (0) and 8, 12 and 24 hs after admission to coronary unit. Percent of obstruction more than 70% stenosis was considerate moderate-severe and less than 30% normal-mild.
Results
No significant differences founded between percent of obstruction in arteries and both groups with low (? 0.01ng/ml) or high (> 0.01ng/ml) values of cTnI, there was not a significant linear correlation between obstruction percent (%) and cTnI levels, there were less patients with cTnI > 0.01ng/ml in normal-mild stenosis at 8 and 12 hs respect to moderate-severe stenosis.
Conclusion
This study allows us to define sensitivity variations at different hours of cTnI respect to coronary stenosis degree in NSTEMI patients.

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