Article


Criteria and Decision Limits of cTnI Sensitivity Respect to Coronary Stenosis in Patients with Non ST-Elevation Myocardial Infarction

Agustín Joison1* & Baiardi Gustavo2

1Department of Biological Chemistry, Córdoba Catholic University, Argentina
2Institute of Biological and Technological Research (IIBYT-CONICET), National University of Córdoba, Argentina

Dr. Agustín Joison, Department of Biological Chemistry, Córdoba Catholic University, Argentina.

Keywords: Cardiac Troponin I; Ischemia; Coronary Stenosis; Thrombosis

Abstract

unstable angina, acute myocardial infarction. These terms are called acute coronary syndrome. Concerning the same it is classified according to the electrocardiogram in ST-elevation myocardial infarction and non STelevation. Cardiac troponin-I as cardiac biomarker allows the myocardial injury in patients and values of serum cTn-I are measured join coronary angiography, at respect the increase in that biomarker is associated to extent of damage and severity of coronary arteries.
Materials and Methods
A descriptive, observational, and random study in 219 patients with non ST-elevation myocardial infarction was develop between 2014 and 2016 in the coronary unit of the “Reina Fabiola” Clinic, Córdoba, Argentina. Cardiac troponin I testing was measured baseline in emergency room (0) and 8, 12 and 24 hs after admission to coronary unit. Percent of obstruction more than 70% stenosis was considerate moderate-severe and less than 30% normal-mild.
Results
No significant differences founded between percent of obstruction in arteries and both groups with low (? 0.01ng/ml) or high (> 0.01ng/ml) values of cTnI, there was not a significant linear correlation between obstruction percent (%) and cTnI levels, there were less patients with cTnI > 0.01ng/ml in normal-mild stenosis at 8 and 12 hs respect to moderate-severe stenosis.
Conclusion
This study allows us to define sensitivity variations at different hours of cTnI respect to coronary stenosis degree in NSTEMI patients.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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