Trimester Dependent Derangements of Fibrinolytic Markers in Maternal P. Falciparum Malaria in Port Harcourt, Nigeria

Stella Urekweru Ken-Ezihuo^1*, Ebirien-Agana Samuel Bartimaeus¹ & Zacchaeus Awortu Jeremiah²

¹Department of Medical Laboratory Science, Rivers State University, Nkpolu-Orowokwo, Port Harcourt, Nigeria
²Department of Medical Laboratory Science, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria

Dr. Stella Urekweru Ken-Ezihuo, Department of Medical Laboratory Science, Rivers State University, Nkpolu-Orowokwo, Port Harcourt, Nigeria.

Keywords: Maternal; Pregnancy; Malaria; Firinolytic Markers

Abstract

The attack of malaria infection in pregnancy, often result to harmful effects which may involve the mother’s health, the baby’s health or both. This study was set to determine the effect of malaria infection in pregnancy on some fibrinolytic markers at different trimester in pregnant women attending the ante-natal clinics in University of Port Harcourt Teaching Hospital and Rivers State University Teaching Hospital Port Harcourt, Nigeria. A total of 160 subjects were recruited into this study- eighty (80) malaria infected pregnant women and 80 non malaria infected pregnant women. Five milliliters (5ml) of venous blood was collected from each subjects into ethylene diamine tetra acetic acid bottles, 3 milliliters of the samples were centrifuged for 15-minutes at 1000rpm within 30 to 45 minutes of collection, the supernatant plasma was withdrawn and transferred into plain tubes and stored in the refrigerator at -20ºC for the estimation of levels of fibrinogen, tissue plasminogen activator, D-dimer, plasminogen activator inhibitor 1, plasminogen activator inhibitor 2, plasminogen and α-2-antiplasmin. The tests were performed using enzyme linked immunosorbent assay.

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