Towards Evading Antibiotic Resistance in Urinary Tract Infections: An Innovative Solution Through Non-Traditional Approach

CuhaWijay Sathiyajith^* & Vijaya Rajendram

Neptune Bio-Innovations Pty Ltd, Unit E4 3-29 Birnie Avenue, Lidcombe, Australia

Dr. CuhaWijay Sathiyajith, Neptune Bio-Innovations Pty Ltd, Unit E4 3-29 Birnie Avenue, Lidcombe, Australia.

Keywords: Urinary Tract Infection; URICIL; Escherichia Coli

Abstract

Burgeoning interest have been directed in the recent past towards antibiotic resistance exhibited by bacterial infections. Currently, global unrestrained use of broad-spectrum antibiotics has been singled out as the prime factor for this devastating issue. Therefore, any efforts to mitigate usage of antibiotics in most common recurrent bacterial infections such as urinary and respiratory tract infections could be considered as a boon to circumvent this global challenge. In this article, we report the novel curcumin formulation composed of potassium citrate as urinary alkaliser along with bioavailable modified curcumin extract as the natural antibacterial agent. The in vitro evaluation of this unique composition proved more than log 5 reduction of E. coli viable bacterial colonies belonging to strain from ATCC25922 with 175µg/mL as the minimum bactericidal concentration (MBC). It was also established that the presence of potassium citrate in the composition does not alter the antibacterial efficacy of the bioavailable modified turmeric extract.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).