Mental and Cognitive Disorders in Older People With Subclinical Thyroid Conditions

Mila Vasilj Mihaljevic1,2, Zvonimir Bosnic3,4, Karolina Veselski5, Domagoj Vucic6, Ljiljana Trtica Majnaric2,4*

1The Health Centre Vukovar, Vukovar, Croatia
2Department of Internal Medicine, Family Medicine and the History of Medicine, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, Osijek, Croatia
3The Health Centre Slavonski Brod, Slavonski Brod, Croatia
4Department of Public health, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 21, Osijek, Croatia
5Department of ENT, Dr. Josip Bencevic General Hospital, Slavonski Brod, Croatia
6Department of Cardiology, Dr. Josip Bencevic General Hospital, Slavonski Brod, Croatia

Dr. Ljiljana Trtica Majnaric, Faculty of Medicine, Department of Internal Medicine, Family Medicine and the History of Medicine & Faculty of Dental Medicine & Health, Dept. of Public Health, University of Osijek, Croatia.

Keywords: Aging; Subclinical Thyroid Conditions; Cognitive Function Decline; Mental Disorders


It is well known that thyroid disorders are associated with impairments in cognitive function and the appearance of symptoms of mental disorders. Thyroid hormone replacement therapy was shown to ameliorate these symptoms. During aging, subtle changes in regulation of the hypothalamus-pituitary- thyroid axis and in serum concentrations of the pituitary thyroid-stimulating hormone (TSH) can be observed, along with decreased sensitivity of peripheral tissues to thyroid hormones. Since decline in cognitive function is concomitant to aging, there is a question on the influence of these subtle changes in serum thyroid hormone concentrations on age-related cognitive decline. Due to the fact that both, the progression of cognitive function decline, and the appearance of symptoms of mental disorders, in older people, are depended on accumulation of comorbidities during aging, associations of these disorders with subclinical thyroid conditions should be assessed in the context of age and the existing comorbidity patterns.

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