Deciphering Controversies About the Effect of Vitamin D in Hepatitis B

Marina Ruxandra Otelea1*, Oana Sandulescu1,2 & Isabela Tarcomnicu2

1Clinical Department 2, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
2National Institute for Infectious Diseases “Prof. Dr. Matei Bals”, Bucharest, Romania

Dr. Marina Ruxandra Otelea, Clinical Department 2, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

Keywords: Vitamin D; Hepatitis B; Vitamin D Binding Protein; Vitamin D Receptor


Chronic infection with hepatitis B virus has a major public health impact. Current antiviral therapy in chronic hepatitis B keeps the infection under control, but does not cure the disease; therefore, different areas of research aiming to reduce the risk of progressive disease are open. Despite numerous experimental data showing a benefit from vitamin D supplementation, clinical studies do not consistently support this finding. This review covers the possible explanations for these controversies, highlighting the complexity of vitamin D metabolism and of hepatitis B virus biology that should be considered for proper comparison of the results of the clinical studies.

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