Coronavirus Disease 19, the Large-Scale Coronavirus Pandemic
Samad Farashi Bonab1, Abdolfattah Sarrafnejad2 & Nemat Khansari1*
1Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Immunology, School of Health, Tehran University of Medical Sciences, Tehran, Iran
Dr. Nemat Khansari, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: RNA; MERS-CoV; COVID-19
Coronaviruses are enveloped viruses possessing a positive-sense single stranded RNA genome and a capsid with helical symmetry. These viruses have the largest genome (26 to 32 kilobases) among RNA viruses. These viruses were termed Coronavirus due to their crown-like morphology under electron microscope.
Coronaviruses infect humans, other mammals, and birds and can cause respiratory, enteric, hepatic, and neurologic diseases as well as kidney and cardiac problems. So far, seven species of coronaviruses are known to cause human disease. Most human corona virus diseases had a zoonotic origin. The four human corona
virus (HCoV)-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1 are endemic and prevalent . Other human coronaviruses include severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are highly transmissible and pathogenic in humans.
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