Neuroendocrine, Sensory, Trabecular: Merkel Cell Carcinoma

Anubha Bajaj

Department of Histopathology, A.B. Diagnostics, India

Dr. Anubha Bajaj, Department of Histopathology, A.B. Diagnostics, India.

Keywords: Cell Carcinoma; Tumour; Lymph Node

Abstract

Preface
Afferent sensory mechano- receptors situated in the basal layer of the epidermis are designated as Merkel cells [1]. The malignant conversion of the merkel cells the pleuri-potent stem cells may engender the Merkel cell carcinoma [2,3]. A neuro-endocrine tumour frequently located in the head and neck of fair skinned adults or elderly males, Merkel cell carcinoma is a contemporary designation for a cutaneous malignancy, previously termed as a trabecular carcinoma, small cell carcinoma, neuro-endocrine or an endocrine carcinoma [4]. Analogous with adjunctive cutaneous malignancies, the sun-exposed regions, face and extremities are commonly implicated. The disease prevalence may be elevated in the immune - suppressed patients. The infrequent, asymptomatic malignancy has amplified up-to four times in the preceding decades [5]. Tumours of the lip, scalp, on-site invasion, lymph node or distant metastasis, tumour reoccurrence and lymphaticvascular invasion are indicators of a poor prognosis. Merkel cell carcinoma may be collated with the malignant melanoma on account of the tumour aggression and an unfavourable outcome. The epidemiology, diagnostic evaluation and therapeutic options are debatable by virtue of the infrequency of the tumour.

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