The Concerns to Use Anti-inflammatory Medicines to Inhibit the Actions of Macrophages

Tirasak Pasharawipas

Department of Medical Technology, Rangsit University, Thailand

Tirasak Pasharawipas, Department of Medical Technology, Rangsit University, Thailand.

Keywords: Macrophages; Antigen-presenting cells; Anti-inflammatory drug

Abstract

The members of the immune cells that play the key roles as the antigen presenting cells (APCs) are macrophages, dendritic cells (DCs) and B lymphocytes. Macrophages and DCs play the critical actions as the APCs to activate naïve T cells to be the effective T cells. With the entire process of their antigen presentation to promote the adaptive immunity to fight against infectious agents, macrophage and DCs also cause unpleasant stage of inflammation. To eradicate inflammation, some medicines especially new discovered herbal drugs have been reported to play a mechanism to inhibit an inflammatory process of macrophages which is blamed to be the main cause of inflammatory-related pathogenesis in many diseases. This article presents the concerns to use anti-inflammatory drugs to inhibit the functions of macrophages. The illusion for the good outcome in a short term of these medicines can cause the subsequent problem by decreasing the immune response of the individuals. The general views of this concern will be discussed.

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