Highlights About Recent Sepsis Related Studies

Badlou, B. A.^1* & Hedayati Ch, M.²

¹BBAdvies and Research, Research and Development Dept. Zeist, The Netherlands
²Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Guilan, Iran

Dr. Badlou, B. A., BBAdvies and Research, Research and Development Dept. Zeist, The Netherlands.

Keywords: Sepsis; Immune System; SRPs

Abstract

Recently sepsis and septic shock are (re-)defined as the new definitions, which emphasis that sepsis as lifethreatening organ dysfunction caused by a dysregulated host response to (concomitant) infection(s) [1,2]. Sepsis in human was described in various forms in about 1000 BC and for the first time defined as an infection in the blood or tissues along with fever by the Persian Philosopher Ibn Sina Zakaria Razi, who was born in the Rey city, Iran (also known as Avicenna) [3,4]. Daily, terminal patients are predominantly dying from the different causes i.e. thrombosis, bleedings disorders, cardiovascular failure, respiratory, metabolic failure with and/or without septic shocks. Sepsis incidence and mortality varied substantially across regions, with the highest burden in sub-Saharan Africa, Oceania, south Asia, east Asia, and southeast Asia [4,5]. There is scant studies published investigating sepsis and septic shock in a human model system, in vivo. Moreover, there are so much aspects unknown concerning either the mechanism of sepsis or inducing system of uncontrolled shot down of different organs after sever septic shocks. After sepsis was recently re-defined as the new proposal concept one could conclude that sepsis is a serious life-threatening process which induces organ dysfunction and random dysregulation of host response to infecting antigens [2-5].

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