Prevention Strategies of Metastatic Cancers by Understanding Key Role of the PLTs Microparticle and Exosomes

Bahram Alamdary Badlou

BBAdvies and Research, Research and Development Dept., Zeist, The Netherlands

Dr. Bahram Alamdary Badlou, BBAdvies and Research, Research and Development Dept., Zeist, The Netherlands.

Keywords: Metastatic Cancer; Microparticle; Exosomes

Abstract

Prevention of the Metastatic of Malignant Cancer Tissue and Cells Proliferation (MMCTCP) is a lifesaving approach for any cancer patient. Although, the possible mechanism is not elucidate completely yet. Song Z et al. have suggested that liquid exosomes can be used as biomarkers for the diagnosis of Lung Cancer (LC). Cells release membrane vesicles in their surrounding medium either constitutively or in response to activating signals [1-5]. Two main types of extracellular vesicles (EVs) are commonly distinguished based on their I. mechanism of formation, II. membrane composition and III. size. The biological EVs shed from the plasma membrane, often called microvesicles (MVs), expose phosphatidylserine (PS) and range in size from 100nm to 1?m, while EVs originating from endosomal multi-vesicular bodies, called exosomes (EXos), contain tetraspanin proteins, including CD63, and range in size from 50 to 100nm [1,3,5]. How MVs and Exos are involved in manipulation of the Cancer-Related mortality and morbidity is not elucidated as well.

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