The Effect of Moringa Oleifera Leaf and Seed Extract on Some Coagulation Parameters in Albino Rats

Okorie Hope & Obeagu Emmanuel Ifeanyi^*

Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria

Obeagu Emmanuel Ifeanyi, Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria.

Keywords: Moringa Oleifera Leaf; Seed Extract; Coagulation Parameters; Albino Rats

Abstract

The effect of moringa oleifera leaf and seed extracts was studied on body weight, and some coagulation parameters of albino rats. Oral administration of 100 and 200mg/kg bodyweight of the rats for 2weeks caused duration and dose. The results revealed a statistically mean difference which is higher platelet counts and higher in prothrombin time and lower in activated partial thromboplastin time in rats treated with fresh moringa leaf extract, dry moringa leaf extract, dry moringa seed extract. There was no significant change in the body weight of rats treated for 2weeks with moringa oleifera leaf and seed extract. Platelet count (210 ± 46.19) and prothrombin time (13± 1.15) were significant increased (p<0.05)in rats treated with 100mg/kg of moringa oleifera leaf and seed extract when compared with those of the control counterparts - (318.75 ± 21.65), (295.5± 19.63) (269.25± 99.3), (16.5± 3.46), (13. ± 2.3), (14.5± 2.31) respectively. With 200mg 1kg of the extracts, platelet count (269.25 ± 24.83), (228.75±83.13), (237.75± 71.88) prothombin time (16.25±5.5), (16.75±4.62), (13.25± 3.17) were significantly increased when compared with their control counterparts and those treated with 100mg 1kg. activated partial thromboplastin time (34.75± 9.52) was significantly decreased in rats treated with 100mg1kg when compared with those of the control (31±4.62), (36.25±9.2), (28.25± 3.117), (36±10.36) and (29.5± 8.66) respectively. These results suggest that moringa oleifera extracts have contains thrombin like enzyme.

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