Preparation of Laboratory Animal Models of S-TBI and Its Clinical Significance

Lu Shou Long^1*, Ying Qi¹, Zhang Feng Lin¹, Xu Xiao Long¹, Tang Yin², Jiao Yong², Wang Quan², Wang Xiao Xi³, Zhang Xiao Li³ & Lu Ning⁴

¹Department of Neurosurgery, Shanghai Naval Hospital, China
2Animal Laboratory and Medical Information, Department of Naval Medical Research Institute, China
3Department of Pathology, Naval Hospital, China
4Information Center of Shanghai Research Institute of Sinopec, China

Dr. Lu Shou Long, Department of Neurosurgery of No.411 Naval Hospital, China.

Keywords: Severe Traumatic Brain Injury; Trauma-Causing Impact; Clinical Significance; Open Decompression

Abstract

Object
To improve the treatment of S-TBI, establish replicable animal patterns of S-TBI in experimental rats, find out the optimum trauma-causing impact force through experiments in 80 rats, and observe the correlation between pathological sections of brain and clinical brain trauma at serial time points after trauma.
Method
An improved free fall apparatus was used to give impacts on the vault of skull of anesthetized rats with a 50-200g weight from a 20-50cm height, the rats were observed for 4hr to 12days after impact, and brain was collected after anesthesia to make 652 pathological sections.

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).