Cannabidiol as a Novel Therapeutic for Skin Treatments

Júlia Scherer Santos1, Luana de Oliveira Costa1, Monique de Rezende Evangelista2, Laura Diogo Fernandes2, Eduarda Barbosa Scaldini Teixeira2, Ester Marques Rosa2, Fabricio Felippe dos Santos3, Maurilio de Souza Cazarim1,2* & Thaís Nogueira Barradas1,2

1Department of Pharmaceutical Sciences, School of Pharmacy, Federal University of Juiz de Fora, Brazil
2BscPharm, School of Pharmacy, Federal University of Juiz de Fora, Brazil
3Pharmaceutical Science Postgraduate Program, Federal University of Rio de Janeiro, Brazil

Dr. Maurilio de Souza Cazarim, Department of Pharmaceutical Sciences, School of Pharmacy & BscPharm, School of Pharmacy, Federal University of Juiz de Fora, Brazil.

Keywords: Cannabidiol; Endocannabinoid System; Psoriasis; Acne; Skin Aging


Cannabinoids display potential therapeutic applications. Regarding cannabidiol (CBD) to skin application, it shows an anti-inflammatory and antioxidant effect. Therefore, it has potential application in the treatment of acne, dermatitis, psoriasis, and in antiaging skin. CBD modulates several receptors of the endocannabinoid system of the skin (ECS) which is are found all over skin components such as fibroblasts, keratinocytes, and sebaceous glands. In this review, CBD applications to skin treatments as well as the proposed mechanisms of action of CBD were described. The reports evaluated CBD effects alone or associated with other ingredient, in vitro or in vivo assays. The clinical trials, although incipient, showed the potential applications of CBD. Moreover, modulation of transient receptors potential channels family is believed to be related to its anti-acne, anti-atopic dermatitis and anti-aging properties. On the other hand, the anti-psoriasis activity is probably related to modulation of G protein-coupled receptor 55 and peroxisome proliferator-activated receptor gamma. The use of CBD for skin disorders is promising. Nonetheless, further research and a better understanding of CBD mechanisms of action are required.

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