Use of Organoids for Anticancer Drug Development

Tripathi, K.^1* & Lazarevic, M.²

¹Internal Medicine, SMT NHL Medical Municipal College, Gujarat, India
²Internal Medicine, Swedish hospital, Chicago, Illinois

Dr. Tripathi, K., Internal Medicine, SMT NHL Medical Municipal College, Gujarat, India.

Keywords: Brain Organoids; Glioblastoma Multiform; Drug Development

Abstract

Much of organoid research has changed the way developmental neuroscience works, providing unprecedented access to human neurodevelopment and function [1-7]. Figure 1 illustrates the timeline in which the neural stem cells (NSC) were cultured [8]. Glioblastoma is a highly malignant brain tumour with significant intratumor heterogeneity, which could be ascribed to Glioblastoma Stem Cells (GSC) activity variations. Using a variety of experimental techniques including quantitatively evaluating lineage trace, clonal size, mutational marker evaluation, and single cell RNA sequencing showed a growing accretion in GBM and outlined the outcome of tumour cells is regulated by a neurogenesis developmental pathway [9-12].

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).