Use of Organoids for Anticancer Drug Development

Tripathi, K.1* & Lazarevic, M.2

1Internal Medicine, SMT NHL Medical Municipal College, Gujarat, India
2Internal Medicine, Swedish hospital, Chicago, Illinois

Dr. Tripathi, K., Internal Medicine, SMT NHL Medical Municipal College, Gujarat, India.

Keywords: Brain Organoids; Glioblastoma Multiform; Drug Development


Much of organoid research has changed the way developmental neuroscience works, providing unprecedented access to human neurodevelopment and function [1-7]. Figure 1 illustrates the timeline in which the neural stem cells (NSC) were cultured [8]. Glioblastoma is a highly malignant brain tumour with significant intratumor heterogeneity, which could be ascribed to Glioblastoma Stem Cells (GSC) activity variations. Using a variety of experimental techniques including quantitatively evaluating lineage trace, clonal size, mutational marker evaluation, and single cell RNA sequencing showed a growing accretion in GBM and outlined the outcome of tumour cells is regulated by a neurogenesis developmental pathway [9-12].

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