Vibrational Spectroscopy Techniques Used in the Analysis of Glycation Products, Water Content in the Dermis of Diabetic Elderly, Healthy Young, Healthy Elderly Women, and in the Interpretation of Goiter, Follicular and Papillary Thyroid Cancer

Claudio Téllez Soto, A.1*, Liliane Pereira Pinto2, Lázaro Medeiros1, Claudio Téllez Zepeda, A.1, Michely Silva, G. P.1, Isamara Tanaka3 & Airton Martin, A.1

1Biomedical Engineering Innovation Center - Biomedical Vibrational Spectroscopy Group. Universidade Brasil -UBr - Rua Carolina Fonseca, 235 - 08230-030 - Itaquera • São Paulo/SP, Brasil
2FEPI-Fundação de Ensino e Pesquisa de Itajubá, Centro Universitário de Itajubá. Av.Dr. Antônio Graga Filhoi, 687-Porto Velho, Itajubá-MG, 35501-002. Brasil
3Hospital São Francisco de Assis-Coordenadora da UTI pediátrica.- Rua Ernesto Duarte, 70 CEP 12311-200. Parque Califórnia-Jacareí-SP. Brasil

Dr. Claudio Téllez Soto, A., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

Keywords: Vibrational Spectroscopic Techniques; Dermal Glycation Products; Dermal Water Content; Diabetic Elderly; Healthy Young; Healthy Elderly Women; Thyroid Cancer; Goiter


In this article we present several vibrational spectroscopic techniques used in the analysis of glycation products and water content in the dermis of diabetic elderly, healthy young, and healthy elderly women, as well as in different types of thyroid cancer, goiter and abnormal lymph nodes. The measurements of the different samples were made using confocal Raman spectroscopy and Fourier transform infrared spectroscopy. When necessary, vibrational assignments were performed by theoretical calculation of the spectra based on the Density Functional Theory (DFT). The spectroscopic techniques were: correction of the spectra baseline, vector normalization, smoothing, second spectral derivative, band deconvolution analysis, spectral subtraction, spectral inversion, analysis of the intensity of the fundamental bands, enhanced infrared absorbance’s and SERS effect.

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