Amyotrophic Lateral Sclerosis Disease: Analytical Methods of Measurement of Therapeutic Agents against the Disease in Biological Fluids

Mbah, C. J.

Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria

Dr. Mbah, C. J., Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

Keywords: Sclerosis; Biological Fluids; Hyphenated HPLC

Abstract

Amyotrophic lateral sclerosis (ALS) is an irreversible most common motor neuron disease in which the upper and lower motor neurons in the motor cortex, brain stem and spinal cord degenerate leading to progressive paralysis and death probably arising from respiratory failure [1-3].
The disease is caused by genetic mutations [4,5], oxidative stress [6], inflammation [7], loss of neurotrophic factors [8], glutamate excitotoxicity [9], mitochondrial dysfunction [10].
Alpha-amino-3-hydroxy-5- methyl-4-isoxazole propionic acid (AMPA) receptors mediate glutamateinduced excitotoxicity in neurodegenerative diseases [11].

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