COVID-19 War, (Non-)Pyrogenic Actions and Reactions

Bahram Alamdary Badlou

PhD Hematology and Drs. Medical Biology, BBAdvies and Research, Research and Development Department, Zeist, The Netherlands

Dr. Bahram Alamdary Badlou, PhD Hematology and Drs. Medical Biology, BBAdvies and Research, Research and Development Department, Zeist, The Netherlands.

Keywords: COVID-19 Biomarkers; Pyrogen; Inflammation


Worldwide, all nations are distressing from the COVID-19 pandemic outbreak with unexpected death rate about one million, which the exact mechanism how systemic blood is responding not elucidated completely [1-4].
According to Wang et al. 2020 data indicated that all patients without or with fever showed significant differences between ‘clinical characteristics’ symptoms. Their data shockingly revealed that none of the other symptoms alone showed significant differences between COVID-19 patients without- or with fever i.e. neither comorbidities like cardiovascular diseases nor CT positive rates, however. There is still some missing links, One might wonder what it is. Reconsideration of the characteristics of severe fevered patients revealed that a significant population of COVID-19 were aged patients. Because of the significantly increased probability of severe events in fevered COVID-19 patients, Wang et al 2020 further checked subgroups and found 5 main differences and association with aging- related diseases namely 1. severe fevered patients were older a median age 57 vs. 42 years; 2. had a higher fraction of primary comorbidity diseases i.e. hypertension; and cardiovascular disease; severe respiratory symptoms; and 3. ground-glass change in chest CT appearance; 4. a decreased lymphocyte count and proportion; but 5. higher levels of CRP median [2].

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