Evaluation of Osseous Regeneration Using Autogenous Bone Graft, Biphasic Calcium Phosphate and Biphasic Calcium Phosphate Combined With Hyaluronic Acid in Critical Sized Rabbit Femoral Defects

Abou Samra, A. A.1*, Nassar, M. M.2, Saudi, H. I.2 & Raghib, A. M.3

1Assistant Lecturer of Oral Medicine and Periodontology, Faculty of Dentistry, Pharos University, Alexandria, Egypt
2Professor of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Tanta University, Egypt
3Professor of Oral Pathology, Faculty of Dentistry, Tanta University, Egypt

Dr. Abeer Ahmed Abou Samra, Assistant lecturer in the Oral Medicine and Periodontology Department, Faculty of Dentistry, Pharos University, Alexandria, Egypt.

Keywords: Bone Regeneration; Bone Substitutes; Autogenous Bone Graft; Biphasic Calcium Phosphate; Beta-Tricalcium Phosphate; Hyaluronic Acid


To compare bone regeneration in critical sized femoral defects in a rabbit model after the application of autogenous graft, biphasic calcium phosphate bone graft and biphasic calcium phosphate bone graft in adjunct to hyaluronic acid gel.
Materials and Methods
6 white New Zealand rabbits about 3-6 months of age were included in this study. Three identical bony defects were created in each femur. Defects are divided into three groups and filled with one of the materials used in this study. Group I: Autogenous bone graft. Group II: Biphasic calcium phosphate (BCP) bone graft and Group III: Hyaluronic acid (HA) gel and BCP. Bone regeneration has been evaluated at 6 and 8 weeks after surgery by means of histological and histomorphometric investigations.

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