Endocytosis as a Regulator of Cancer Signaling

Raj Sewduth

Department of Oncology, Vesalius Research Center, - KU Leuven, Leuven, Belgium

Raj Sewduth, Department of Oncology, Vesalius Research Center, - KU Leuven, Leuven, Belgium.

Keywords: Endocytosis, Trafficking, Signaling, Cancer, Wnt, ERK, Notch, P53, EGFR, GSK3

Abstract

Endocytosis has recently emerged as a regulator of various pathways. Several of them are implicated in tumorogenesis. Vesicular trafficking of receptors can promote or down regulate pathways, depending on the type of vesicles (clathrin or caveolin dependent) or the end result of the endocytic process (recycling or degradation). Different pathways have been shown to be modulated by endocytosis, such as Wnt/ Erk/ P53/ Ras signaling. These pathways are activated in several types of cancers. Some receptors such as EGFR have even been shown to be mutated on residues essential for its endocytosis in specific cancers.

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