HMGA1-Pseudogenes: A Paradigm of Competitive Endogenous RNA Mechanism

Marco De Martino^* & Francesco Esposito

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli “Federico II”, via Pansini 5, 80131 Naples, Italy.

Marco De Martino, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e hirurgia di Napoli, Università degli Studi di Napoli “Fe

Keywords: HMGA; Pseudogenes; Genetic Mutations; Lymphoid Pathology

Abstract

The genome of humans has been completely decrypted and, surprisingly, protein products are encoded by just 2% of our genes. Now, the leading goal of the scientific community is to unveil the dark matter inside the other 98% of the genome. Up to date, several studies underline that the mammalian genome gives rise to a great number of unidentified transcripts called “non-coding RNA” (ncRNA), whose functions have not been entirely clarified. Among the ncRNA class, pseudogenes are usually defined as genetic relicts, since they lost their capability to produce functional proteins due to the acquisition of new genetic mutations.

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