Fractures in Osteopetrosis: Two Case Reports and Review of the Literature
Zhang Wupeng, Yang Yongliang, Xu Shihong, Wang Fengrui, Tu Yi, Wang Bomin & Wang Fu*
Department of Emergency trauma, Shandong Provincial Orthopedic Hospital, Provincial Hospital Affiliated to Shandong University, Jinan, China
Dr. Wang Fu, Department of Emergency trauma, Shandong Provincial Orthopedic Hospital, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Keywords: Osteopetrosis; Albers - Schnberg Disease; Genetic Disorders; Giagnosis and Treatment
The occurrence of osteopetrosis is related to the function defect or the decrease of the number of osteoclasts, which is characterized by the abnormal activity of osteoclasts, bone resorption defect and bone sclerosis, and eventually leads to the increase of bone density, the narrowing or even disappearance of bone marrow cavity, and the brittle bones. The disease was first reported by German radiologist albers-schnberg in 1904. The disease is obviously hereditary and familial. According to the classification, there are different clinical manifestations in different systems of human body. At present, there is no clear incidence statistics in China, and most of the introductions about this disease at home and abroad are case reports. In this paper, the classification, diagnostic evaluation and treatment principles of osteopetrosis were reviewed by reviewing the literature and combining with two patients with osteopetrosis diagnosed and treated in our hospital, so as to provide clinical references for the diagnosis and treatment of osteopetrosis and improve the level of diagnosis and treatment of osteopetrosis.
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