Role of Epigenetics in the Planning of Surgeries, a Review and a Proposal to be Considered

Rafael Iñigo Pavlovich

Department of Musculoskeletal Diseases, Ti Orthopedica Institute, Mexico

Dr. Rafael Iñigo Pavlovich, Department of Musculoskeletal Diseases, Ti Orthopedica Institute, Mexico.

Keywords: Epigenetics; Oxidative Stress; Diabetes Mellitus

Abstract

Beyond question, surgeries in general impose a stress on the patient, emotionally [1] and biological triggering chemical alarm systems, which can affect the results of the surgery [2-4]. A high level of oxidative stress is a very important factor in a low immunity and hence potential complications are generated. Toxic substances in sterile inflammations such as myeloperoxidase [5] can achieve a compromised immune system response; even antibiotics may generate reactive species of oxygen that causes oxidative stress, membranes and cellular DNA damage [6]. Patients with conditions such as diabetes [7], arthritis, autoimmune diseases [8], cellular senescence [9], excessive inflammation [10] already may suffer high levels of oxidative stress, bringing forth a statistic of higher complications, such as infections [11], scarring [9], increased mortality [12], among others.

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