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In Vitro Evaluation of the Antioxidant and Urease Inhibition Activities of Three Triterpenes from the Flowers of Alstonia Scholaris

Nighat Sultana1* & Muhammad Saleem1,2

1Pharmaceutical Research Center, PCSIR Laboratories Complex, Karachi-75280, Pakistan
2Departments of Biotechnology, University of Karachi, Karachi, Pakistan

Dr. Nighat Sultana, Pharmaceutical Research Center, PCSIR Laboratories Complex, Karachi-75280, Pakistan.

Keywords: In Vitro Evaluation; Urease Inhibition; Flowers

Abstract

Reinvestigation of the flowers of Alstonia scholaris of Pakistan origin have resulted in the isolation of three triterpenoids, two of the ursane type, 3 β -acetate- 24-nor- urs-4, 12-diene ester triterpene (1), 3 β -hydroxy- 24-nor-urs-4,12,28-triene triterpene (2) and one of the oleanane type 3,28- β -diacetoxy-5-olea-triterpene (3) together with two known triterpenes α-amyrin acetate (4) and ursolic acid (5). These compounds were analyzed for antioxidant and antiurease inhibition tests. Compounds 2 and 4 were subjected to enzymatic bioassays. Compounds 2 and 4 were found to be antioxidant with IC50 107±0.39

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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