Revisiting What Might Save Life of Cancer Patients Actually

Bahram Alamdary Badlou

Research and Development Department, Zeist, The Netherlands

*Correspondence to: Dr. Bahram Alamdary Badlou, Research and Development Department, Zeist, The Netherlands.

Copyright © 2019 Dr. Bahram Alamdary Badlou. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cancer patients 5-years survival chance (5YSC) is still after a Century research and development (R&D)do not changed significantly, as infectious diseases did. How Medici might increase 5YSC is not elucidated yet.

Recently I introduced death triangle machinery (DTM), which might play pivotal role in accelerating 5YSC toward increased morbidity and mortality rate in the last years [1].

Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by auto-antibodies against platelet GPIIbIIIa and/or the GPIb-receptor complex. Current theory suggests that (auto-) antibody-mediated platelet destruction occurs in the spleen, via macrophages through Fc-FcγR interactions [2]. June Li et al 2015 postulated that their findings shed light on Fc-independent cytopenias, designating desialylation as a potential diagnostic biomarker and therapeutic target in the treatment of refractory ITP [2]. Recall, refractory ITP is defined as severe ITP after splenectomy.

Glucocorticoids remain the standard, first-line therapy for IT, which is regularly occurs during the first 5 years treatments of cancer patients, however. The goal of first line therapy of ITP tends not to be a cure or remission but rather to maintain a safe platelet count that will prevent bleeding while minimizing the side effects of the cancer-related medications. Wong RSM et al. 2017 showed hepatobiliary adverse events i.e. cataracts, deep vein thrombosis, cerebral infarction, headache, and myelofibrosis occurred in more than 1 patient; the remaining adverse events occurred only once. Rates of thromboembolic events, and hepatobiliary adverse events did not increase with treatment duration past 1 year. Recall, one of the most important side effects in cancer patients after routine cancer treatments i.e. Surgery, Chemotherapy, and Radiotherapy is bleeding disorder internally and acute/ chronic Deep venous thrombosis [3] thrombolytic processes [4], eventually.

The systemic immune-inflammation index (SII) has been reported to be associated with patient survival in various kinds of solid tumors [5] Esophageal cancer (EC) is currently the fifth most commonly diagnosed malignancy and the fourth leading cause of cancer deaths in China [6].

Taken together, soft and hard solid cancers and their related DTM are remaining leading death causes, which both results in too high costs, and too much pain for patients and their relatives. In the 21th Century, One might expect from the Policymakers that accelerate merely the study groups and their model systems, which have shown positive influence to unravel / halting all kinds of cancerogenous processes, in the last decade, and not older/ others. This kind of financial approaches might stimulate novel idea and alternatives compared to old fashion ones. Who knows might affect also the 5YSC of cancer patients as well.

Bibliography

1. Bahram Alamday Badlou (2018). Thrombotic Disorder Correlates with ‘Death Triangle’ Machinery. Acta Scientific Cancer Biology, 2(10), 01-02.
2. Li, J., van der Wal, D. E., Zhu, G., Xu, M., Yougbare, I., Ma, L., et al. (2015). Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nat Commun., 6, 7737.
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5. Yibo Gao, Wei Guo, Songhua Cai, Fan Zhang, Fei Shao, Guochao Zhang, Tiejun Liu, et al. (2019). Systemic immune-inflammation index (SII) is useful to predict survival outcomes in patients with surgically resected esophageal squamous cell carcinoma. J Cancer., 10(14), 3188-3196.
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