CPQ Medicine (2020) 10:5
Research Article

Dispensing of Common Antibiotics at Various Pharmacies in Karachi, Pakistan

Salman Ashfaq1, Nighat Razvi2, Fakhsheena Anjum3* & Syed Imran Ali4

1Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
2Faculty of Pharmacy, Nazeer Hussain University, Karachi, Pakistan
3Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan
4Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan

*Correspondence to: Dr. Fakhsheena Anjum, Faculty of Pharmaceutical Sciences, Dow University of Health Sciences, Karachi, Pakistan.

Copyright © 2020 Dr. Fakhsheena Anjum, et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 17 October 2020
Published: 27 October 2020

Keywords: Pharmacist; Pharmacy; Antibiotics; Dispensing


The irrational use of antibiotics in various diseases can be detrimental to health and can promote the resistance too. The patients should be counseled about the use of antibiotic by healthcare professionals, particularly by the pharmacists, at the time of dispensing. This study was conducted to identify the availability of pharmacists at various pharmacies in Karachi, Pakistan and patient counseling during dispensing. The questionnaires were distributed among n=71 pharmacies from January 2016 to December 2016 which were situated in various districts of Karachi. The completed questionnaires were collected from the pharmacies, which were coded and then analyzed using SPSS version 23. The results have shown that the pharmacists were available only in n=40 (56.34%) pharmacies situated in the districts of Karachi, (i.e. South, East, West, Central and Malir) and they were also engaged in patient counseling. Most of the prescriptions were dispensed from district central (56.3%) and then by district east (32.4%). This may owe to the larger number of people residing there as compared to other districts. Prescriptions for some common antibiotics (i.e. Amoxicillin, Ceftriaxone and Moxifloxacin) were evaluated and it was observed that n=1500 prescriptions of Amoxicillin, n=200 of Ceftriaxone and n=525 of Moxifloxacin on an average were dispensed by the pharmacies on monthly basis. In general, out of about n=2961 prescriptions, approximately n=1224 were dispensed as self- medication from these pharmacies. Pharmacy professionals should be available at all the pharmacies of Karachi who can dispense the drugs safely and can also counsel the patients about their medicines; self- medication should be discouraged at all levels as such practices can lead to adverse health consequences.

Dispensing of medicines is an important part of pharmacy practice, and its drill has grown due to increasing responsibilities towards patients [1]. The pharmacist is central to the pharmacotherapeutic process and dispenses drugs correctly and safely [2,3]. Pharmacies are considered as the sites where purchase of medicines is done along with exchange of information and advice on common health problems with their treatment [4]. Antibiotics are widely used for the treatment of infections which not only cure the infections but also promote the development of resistance against the use of antibiotics [5]. Irrational use of antibiotics has been reported worldwide [6,7]. Also, it has been reported that in some of the developed countries the antibiotics are being purchased as an over the counter drug [8-11]. Unfortunately, almost any drug can be purchased over the counter in less developed countries [4]. There has been an increase in the prevalence of antimicrobial resistance due to non-judicious use of antibiotics [12,13].

Usually people with complaint of disease seek for over the counter (OTC) medicines either for selfmedication or for pharmacists’ advice in a community pharmacy. Self‑medication can potentially contribute to antibiotic resistance in humans. It is necessary to emphasize about its adverse consequences to the community [14]. The increasing trend towards self-medication highlights the need for patient’s counselling for proper drug use [1]. A study carried out on the children in Saudi Arabia revealed that antibiotics were being prescribed by the physicians excessively and the patients themselves were also taking the antibiotics without the prescription from the medical shops [15]. In Pakistan, a research reported that 13.45% of the total prescribed medicines comprised of antimicrobial drugs, while there were 45.19% of the prescriptions in which there was at least one antibiotic prescribed to the patients [16].

The study was carried out by distributing the questionnaires in the pharmacies from January 2016 to December 2016. (n=71). The questionnaires were given to different pharmacies located in various districts of Karachi, i.e. South, East, West, Central and Malir. Pharmacy supervisors were asked to provide the required information, after briefing them about the purpose of study. The questionnaire comprised of information about the number of qualified persons working in each pharmacy, number of antibiotic prescriptions received for dispensing, number of patients asking for antibiotics for self-medication, the number of prescriptions received particularly for Amoxicillin, Ceftriaxone and Moxifloxacin per month and patient counseling by the pharmacists for proper drug use. For the statistical analysis, the responses obtained in the completed questionnaires from the pharmacies were coded and then analyzed via SPSS (Statistical Package for Social Sciences), version 23.

Majority responses were received by the pharmacies of central district (56.3%) and district east (32.4%) which could owe to the large number of population residing there. The table displays information regarding establishment of pharmacies, number of patients visiting them per month and dispensing of antibiotics. The figure elaborates dispensing of common antibiotics from the pharmacies in a month, district-wise in Karachi. It was found that pharmacists were working only in n=40 (56.34%) pharmacies out of n=71, who were also doing patient counseling for proper drug use.

Table: Information about the pharmacies under study

Figure: Antibiotics (Amoxicillin, Ceftriaxone & Moxifloxacin) dispensed from various pharmacies in Karachi in a month

The literature from various studies suggests that among variety of different medicinal agents, antibiotics are frequently purchased worldwide. Although they are particularly very useful for the infectious diseases but their increased use has led to development of antibiotic resistance [17-19]. The data obtained in this study from pharmacies located in various regions of Karachi indicate frequent dispensing of antibiotics per month (Figure & Table). This is in line with a study that reported antibiotics as the frequently sold drugs to treat infections in the developing countries of the world [18]. Self-medication was also being found practiced by the residents of Karachi (Table). It correlates with the work of Högberg et al. (2014) [20] and Morgan et al. (2011) [21] which stated that self-medication is a frequent practice of people in major different regions of the world and around 50% of the antibiotics which are used by the people are purchased without a prescription.

The figure shows that the total amount of Amoxicillin dispensed in various districts of Karachi is highest in contrast with Ceftriaxone and Moxifloxacin. This data is comparable with the study conducted by de Jong et al. (2008) [22] which identified Amoxicillin as the most prescribed antibiotic among different types of antibiotics included in the study. Another study concluded Cephalosporin (81.50%) as the most frequently prescribed class of antibiotics [23].

The table indicates the purchase of antibiotics without prescription from the pharmacies which has been reported by various studies [8-11]. The non-availability of pharmacists in all the pharmacies of Karachi is reported in this study though the pharmacists are an integral part of the pharmacotherapeutic process [2,3]. People seek for OTC drugs for self-medication or upon pharmacists’ advice for their ailments. The irrational use of antibiotics can lead to an increase in the prevalence of antimicrobial resistance [12,13]. It is necessary to accentuate the adverse consequences of self-medication to the community [14] and this can be done by the pharmacists at various pharmacies where purchase of medicines can be done along with exchange of information and advice to consumers on their health problems and treatment [4].

The placement of pharmacy professionals in all the pharmacies of Karachi is necessary who can counsel the patients about their medicines and discourage self- medication practices, which may aid in lowering the levels of antibiotic resistance in the communities.


  1. Negru, D. S., Cristea, A. N. & Petculescu, A. M. (2012). Patient counselling at dispensing OTC medicines in the community pharmacy. Farmacia, 60(1), 102-110.
  2. Galato, D., Alano, G. M., Trauthman, S. C. & Vieira, A. C. (2008). The dispensation of medicines: a reflection for prevention, identification and solution of drug related problems. Revista Brasileira de Ciências Farmacêuticas, 44(3), 465-475.
  3. Obreli-Neto, P. R., Pereira, L. R. L., Guidoni, C. M., de Oliveira Baldoni, A., Marusic, S., de Lyra-Júnior, D. P., et al.. (2013). Use of simulated patients to evaluate combined oral contraceptive dispensing practices of community pharmacists. PLoS One, 8(12), e79875.
  4. Rabbani, F., Cheema, F., Talati, N., Siddiqui, S., Syed, S., Bashir, S., Zuberi, L., Shamim, A. & Mumtaz, Q. (2001). Behind the counter: pharmacies and dispensing patterns of pharmacy attendants in Karachi. JPMA: Journal of the Pakistan Medical Association, 51(4), 149.
  5. Ullah, A., Kamal, Z., Ullah, G. & Hussain, H. (2013). To determine the rational use of antibiotics; A case study conducted at medical unit of Hayatabad Medical Complex, Peshawar. International Journal of Research in Applied, Natural and Social Sciences, 1(2), 61-68.
  6. Alhomoud, F., Aljamea, Z., Almahasnah, R., Alkhalifah, K., Basalelah, L. & Alhomoud, F. K. (2017). Self-medication and self-prescription with antibiotics in the Middle East-do they really happen? A systematic review of the prevalence, possible reasons, and outcomes. International Journal of Infectious Diseases, 57, 3-12.
  7. Pechere, J. C., Hughes, D., Kardas, P. & Cornaglia, G. (2007). Non-compliance with antibiotic therapy for acute community infections: a global survey. International Journal of Antimicrobial Agents, 29(3), 245-253.
  8. Anjum, F., Ahmed, S., Rasool, S., Khan, J. & Faiza, S. (2019). Antibiotics and Their Resistance: Assessment of Knowledge among Final Year Pharm. D Students. CPQ Medicine, 6(2), 1-8.
  9. Banerjee, I., Sathian, B., Gupta, R. K., Amarendra, A., Roy, B., Bakthavatchalam, P., Saha, A. & Banerjee, I. (2016). Self-medication practice among preclinical university students in a medical school from the city of Pokhara, Nepal. Nepal Journal of Epidemiology, 6(2), 574-581.
  10. Cars, O. & Nordberg, P. (2005). Antibiotic resistance-The faceless threat. International Journal of Risk & Safety in Medicine, 17(3,4), 103-110.
  11. Lansang, M. A., Lucas-Aquino, R., Tupasi, T. E., Mina, V. S., Salazar, L. S., Juban, N., Limjoco, T. T., Nisperos, L. E. & Kunin, C. M. (1990). Purchase of antibiotics without prescription in Manila, the Philippines. Inappropriate choices and doses. Journal of clinical epidemiology, 43(1), 61-67.
  12. BP, S. K., YL, S., Ahamed, M. G. & MR, N. (2011). Survey On Knowledge Towards Antibiotics Among The Nursing Students. International Journal of Pharmacy and Pharmaceutical Sciences, 3(2), 227-229.
  13. Shehadeh, M., Suaifan, G., Darwish, R. M., Wazaify, M., Zaru, L. & Alja’fari, S. (2012). Knowledge, attitudes and behavior regarding antibiotics use and misuse among adults in the community of Jordan. A pilot study. Saudi Pharmaceutical Journal, 20(2), 125-133.
  14. Bennadi, D. (2013). Self-medication: A current challenge. Journal of basic and Clinical Pharmacy, 5(1), 19-23.
  15. Alumran, A., Hou, X. Y. & Hurst, C. (2013). Assessing the overuse of antibiotics in children in Saudi Arabia: validation of the parental perception on antibiotics scale (PAPA scale). Health and Quality of Life Outcomes, 11(1), 39.
  16. Das, N., Khan, A., Badini, Z., Baloch, H. & Parkash, J. (2001). Prescribing practices of consultants at Karachi, Pakistan. Journal of the Pakistan Medical Association, 51(2), 74-77.
  17. Hameed, A., Naveed, S., Qamar, F., Alam, T., Abbas, S. & Sharif, N. (2016). Irrational use of antibiotics. Different Age Groups of Karachi: a wakeup call for antibiotic resistance and future infections. J Bioequiv Availab., 8(5), 242-245.
  18. Nepal, G. & Bhatta, S. (2018). Self-medication with antibiotics in WHO Southeast Asian Region: a systematic review. Cureus., 10(4), 1-17.
  19. Schirm, E., Van Den Berg, P., Gebben, H., Sauer, P. & De Jong‐van den Berg, L. (2000). Drug use of children in the community assessed through pharmacy dispensing data. British Journal of Clinical Pharmacology, 50(5), 473-478.
  20. Högberg, L. D., Muller, A., Zorzet, A., Monnet, D. L. & Cars, O. (2014). Antibiotic use worldwide. The Lancet Infectious Diseases, 14(12), 1179-1180.
  21. Morgan, D. J., Okeke, I. N., Laxminarayan, R., Perencevich, E. N. & Weisenberg, S. (2011). Non-prescription antimicrobial use worldwide: a systematic review. The Lancet Infectious Diseases, 11(9), 692-701.
  22. de Jong, J., van den Berg, P. B. & de Vries, T. W. (2008). Antibiotic drug use of children in the Netherlands from 1999 till 2005. European Journal of Clinical Pharmacology, 64(9), 913-919.
  23. Atif, M., Azeem, M., Sarwar, M. R., Shahid, S., Javaid, S., Ikram, H., Baig, U. & Scahill, S. (2016). WHO/INRUD prescribing indicators and prescribing trends of antibiotics in the Accident and Emergency Department of Bahawal Victoria Hospital, Pakistan. Springerplus, 5(1), 1-7.

Total Articles Published



Cient Periodique is a ‘Gold’ open access publisher that aspires to offer absolute free, unrestricted access to the valuable research information

We welcome all the eminent authors to submit your valuable paper

Cient Periodique invites the participation of honourable Editors and Authors

CPQ Journals provide Certificates for publication

Cient Periodique also offers memberships for potential Authors

Best Articles will be appreciated with the provision of corresponding Certificate