Is the In Vitro Generated Autologous Bone Graft is Round the Corner?
Nahum Rosenberg, MD, FRCS
Department of Orthopaedic Surgery, Israel
Nahum Rosenberg, MD, FRCS, Department of Orthopaedic Surgery, Rambam Health Care Campus, Israel.
Keywords: Autologous Bone Grafts; Osteoblast Cells; Inorganic Fillers; Bone Marrow; Engineered Bone
Bone has a vigorous potential to regenerate itself after damage; however, the efficacious repair of large defects resulting from resection, trauma, extended fractures or inadequately vascularized bone gaps will not achieve a satisfactory healing and will be considered as nonunion [1]. Up-to 10% of patients will experience a nonunion bone gap and will require implantation of bone grafts. Cumulatively, 500,000 surgical cases of bone grafting procedures are taking place annually in the US alone [2]. Importantly, the demand for bone grafts is expected to be even greater over the next decade as the population ages and life expectancy increases [1].
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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