Monoterpenes -A Class of Terpenoid Group of Natural Products as a Source of Natural Antidiabetic Agents in the Future -A Review

Kulvinder Kochar Kaur^1*, Gautam Allahbadia² & Mandeep Singh³

¹Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, G.T.B. Nagar, Jalandhar, Punjab, India
²Scientific Director, Ex-Rotunda-A Centre for Human reproduction, Kalpak Garden,Perry Cross Road, Mumbai, India
³Consultant Neurologist, Swami Satyanand Hospital, Ladowali Road, Jalandhar, Punjab, India

Dr. Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, G.T.B. Nagar, Jalandhar, Punjab, India.

Keywords: Monoterpenes; T2DM; Obesity; PPAR ?; AMPK; GLUT-4; Myogenesis

Abstract

Monoterpenes are natural products from the terpenoid class and get synthesized with the use of mevalonic acid. They have small molecular weight and are nonpolar in nature, which, makes them the most large components of essential oils that are mostly considered to have some antioxidant and antimicrobial effects at quiet a large concentration. Recently they have been reported to have antidiabetic effects. In view of the indigineous biosynthesis that occurs in nature, they show lot of structural complexity and diversity that needs future structure activity analysis. In this review how monoterpenes may use different mechanisms for antidiabetic activity both by in vitro and in vivo animal studies is discussed. Both the aglycones and glycosides of these very small compounds show antidiabetic activity besides antiobesity and lipid lowering properties.

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