IGG 4 Related Diseases, Are We Under or over Diagnosing?? Clinical Observations in UAE

Makki Fayadh, H.^* & Salim Sabih, A.

Consultant Physician & Gastroenterologist, Advanced Center For Day Care Surgery-Abu Dhabi –UAE

Dr. Makki Fayadh, H., Consultant Physician & Gastroenterologist, Advanced Center For Day Care Surgery-Abu Dhabi -UAE.

Keywords: IgG4-RD; Tissue Fibrosis; Psoriasis

Abstract

During our practice, over last 40 years we have seen many missed diseases related possibly to IgG4 related disease, an example of that, suspected pancreatic cancer proved to be inflammatory in nature (autoimmune pancreatitis), many cases of hepatobiliary diseases, and in one case diagnosis was made of sclerosing cholangitis with ulcerative colitis proved to be IgG4 related diseases after 7 years.
From our recent experience in Abu Dhabi in our center, we came across many cases of elevated IgG4 associated with inflammatory bowel diseases especially ulcerative colitis and hepatobiliary diseases simulating sclerosing cholangitis, multiple autoimmune diseases including thyroiditis, eczema, prostatitis and pachymeningitis.
In all these IgG4 was twice the normal but the real link to the disease whether it is primary cause of the disease or associated phenomena is not yet settled.

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