Neurotherapy: Regeneration of Myelin Sheath by Utilizing Stem Cell Therapy
Department of Pharmacy, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia
Dr. Omar ElFar, Department of Pharmacy, University of Nottingham Malaysia Campus, Semenyih, Selangor, Malaysia.
Keywords: Orphan Drugs; Regulation; Safety; Sustainability; Budget Law
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. It affects the brain and spinal cord nerves that send messages throughout the body. In MS, the immune system attacks myelin, a sheath-like membrane that covers and protects your nerves. It also can damage the actual nerves. The method used to treat Multiple Sclerosis is Qualitative method because it depends more on observation in the Microscope and in vitro tests. Multiple Sclerosis causes the immune cells to differentiate to B-Cells to plasma cells to release antibodies against myelin sheath cells and Oligodendrocytes. In this case, the solution is to decrease B-Cells activity and commence to differentiate pluripotent stem cells to Oligodendrocytes which releases myelin sheath cells to regenerate sclerosis parts. Utilizing Ocrelizumab which is a type of drug called a monoclonal antibody drug which is approved by the FDA. Then to identify oligodendrocytes amino acid and glycoprotein sequence to culture new stem cells with the same receptors.
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