The Relation of Primary and Subclinical Hypothyroidism in Saudi Patients with Type 2 Diabetes Mellitus with Their Glycemic Control

Khalid S. Aljabri, MD, FRCPC, FACP* & Emmad I. Alghannami, MD

Department of Endocrinology, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia

Dr. Khalid S. Aljabri, Department of Endocrinology, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia.

Keywords: Hypothyroidism; Glycemic Control and Type 2 Diabetes

Abstract

Background and Objective
The association between type 2 diabetes mellitus (T2DM) with primary (PH) and subclinical hypothyroidism (SCH) were reported. Thus, we conducted a cross section study to find out the relationship between T2DM with PH and SCH in Saudi patients with T2DM.
Design
A cross-sectional study was conducted in the Diabetes centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia from January 2018 to December 2018. Thyroid stimulating hormone (TSH), free thyroxin (FT4) and HbA1c were measured.
Results
A total of 1022 subjects with T2DM were included in this study. Average age of the study population was 55.4 ±16.1 years. We found 31.4% were male and 68.6% were female. Mean HbA1c (%), TSH and FT4 were 7.0 ±1.5, 3.5 ±5.7mIU/l and 13.5 ±2.9pmol/L respectively. PH and SCH were present in 9.1% and 10.4% where PH was non-statistically significant older than SCH and euthyroid patients (p=0.2). Moreover, females were non-statistically significant more prevalent than males (p=0.1). HbA1c was statistically significant higher in PH compared to SCH or euthyroid patients (7.8 ±2.0, 7.2 ±1.6 and 6.8 ±1.3 respectively, p<0 p=0.002).

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).