An Overview of Anticoagulants

Mohammad Shoaib Hamrah^1*, Mohammad Hassan Hamrah^2,6, Mohammad Hussain Hamrah^3,6, Ahmad Edris Hamrah⁵, Toba Dahi⁴, Mohammad Naim Musammen⁵ & Mohammad Hashem Hamrah⁶

¹Center for Rural Health, School of Health Sciences, University of Tasmania
²Faculty of Stomatology, Kunduz University, Kunduz, Afghanistan
³Arya University Faculty of Medicine, Mazar-i-Sharif, Afghanistan
⁴Faculty of Dentistry, AbantIzzet Baysal University, Bolu, Turkey
⁵Faryab Public Health Department
⁶Dr. Mohammad Hashem Hamrah’s Curative Clinic

Dr. Mohammad Shoaib Hamrah, Center for Rural Health, School of Health Sciences, University of Tasmania.

Keywords: Anticoagulants; Thrombin Inhibitors; Vitamin K

Abstract

Anticoagulant therapy remains the mainstay of medical therapy and prevention of venous thromboembolic disease for many years. The use of traditional anticoagulants is required to strict laboratory control of their efficiency in terms of both insufficient and excessive dosage. They have many limitations such as unpredictable pharmacologic and pharmacokinetic responses and various adverse effects including serious bleeding complications. Recently several new oral anticoagulants have been developed and are expected to replace older agents with their ease of use and more favorable pharmacodynamic profiles. The main adverse effect of all anticoagulants is hemorrhage. Therefore, it is a crucial point for clinicians to have a better understanding of anticoagulant pharmacology, dosing, and toxicity.

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