An Overview of Anticoagulants

Mohammad Shoaib Hamrah1*, Mohammad Hassan Hamrah2,6, Mohammad Hussain Hamrah3,6, Ahmad Edris Hamrah5, Toba Dahi4, Mohammad Naim Musammen5 & Mohammad Hashem Hamrah6

1Center for Rural Health, School of Health Sciences, University of Tasmania
2Faculty of Stomatology, Kunduz University, Kunduz, Afghanistan
3Arya University Faculty of Medicine, Mazar-i-Sharif, Afghanistan
4Faculty of Dentistry, AbantIzzet Baysal University, Bolu, Turkey
5Faryab Public Health Department
6Dr. Mohammad Hashem Hamrah’s Curative Clinic

Dr. Mohammad Shoaib Hamrah, Center for Rural Health, School of Health Sciences, University of Tasmania.

Keywords: Anticoagulants; Thrombin Inhibitors; Vitamin K


Anticoagulant therapy remains the mainstay of medical therapy and prevention of venous thromboembolic disease for many years. The use of traditional anticoagulants is required to strict laboratory control of their efficiency in terms of both insufficient and excessive dosage. They have many limitations such as unpredictable pharmacologic and pharmacokinetic responses and various adverse effects including serious bleeding complications. Recently several new oral anticoagulants have been developed and are expected to replace older agents with their ease of use and more favorable pharmacodynamic profiles. The main adverse effect of all anticoagulants is hemorrhage. Therefore, it is a crucial point for clinicians to have a better understanding of anticoagulant pharmacology, dosing, and toxicity.

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