Current Development in Biocatalysis: Biocatalyst Engineering

Guang Yang, Ph.D.

Department of Process Development, Boston Institute of Biotechnology, USA

Dr. Guang Yang, Department of Process Development, Boston Institute of Biotechnology, USA.

Keywords: Pharmaceutical Industry; Biocatalyst Engineering; Catalysis; Sustainable Chemistry


Modern drug manufacturing faces both ecological and economic challenges. Catalyst, one of the key components in the synthesis of active pharmaceutical ingredients (APIs), also plays a crucial role in the production pipeline. Although being used widely in industrial process, transition-metal catalysts still seem both costly and inefficiently, owing to the expense and toxicity of metals [1]. The emphasized “green” and sustainable chemistry nowadays requires improvement and revolution in the pharmaceutical industry. Sheldon’s environmental factor [2], also known as E-factor, defined as the mass ratio of waste against product in a chemical process, is one of the gauges assessing the process ecology. Based on Sheldon’s analysis, the E-factor of pharmaceutical processes are 25-100, comparing to 0.1 of oil refining and <1-5 of bulk chemical production.

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