Spermidine Associated to Non-Surgical Treatment of Periodontal Disease: Split Mouth Randomized Controlled Clinical Trial
Daniela Carmagnola1, Carlo Angelo Ghisalberti2, Gaia Pellegrini1*, Lucrezia Cinquanta3, Marilisa Toma1 & Claudia Dellavia1
1Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, via Mangiagalli, Milan, Italy
2Department of Biomedical Science for Health, Università degli Studi di Milano, via Mangiagalli, Milan, Italy
Dr. Gaia Pellegrini, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, via Mangiagalli, Milan, Italy.
Keywords: Spermidine; Non-Surgical Therapy; Periodontal Disease Treatment
Spermidine is an endogenous polyamine whose increase induces the autocrine remodeling into targeted cells. The aim of the present study was to evaluate the adjunctive beneficial effects of the local delivery of spermidine to periodontal non-surgical therapy on reduction of periodontal pocket.
In this split mouth, blind, randomized controlled clinical trial, 20 patients with severe chronic generalized periodontal disease scheduled for cause related non-surgical periodontal treatment were enrolled.
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