Spermidine Associated to Non-Surgical Treatment of Periodontal Disease: Split Mouth Randomized Controlled Clinical Trial

Daniela Carmagnola¹, Carlo Angelo Ghisalberti², Gaia Pellegrini^1*, Lucrezia Cinquanta³, Marilisa Toma¹ & Claudia Dellavia¹

¹Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, via Mangiagalli, Milan, Italy
²Department of Biomedical Science for Health, Università degli Studi di Milano, via Mangiagalli, Milan, Italy

Dr. Gaia Pellegrini, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, via Mangiagalli, Milan, Italy.

Keywords: Spermidine; Non-Surgical Therapy; Periodontal Disease Treatment

Abstract

Objectives
Spermidine is an endogenous polyamine whose increase induces the autocrine remodeling into targeted cells. The aim of the present study was to evaluate the adjunctive beneficial effects of the local delivery of spermidine to periodontal non-surgical therapy on reduction of periodontal pocket.
Methods
In this split mouth, blind, randomized controlled clinical trial, 20 patients with severe chronic generalized periodontal disease scheduled for cause related non-surgical periodontal treatment were enrolled.

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