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Volume 1 Issue 4
Bridging Predisposition to an Early Detection in Cancer: D1853N Polymorphism and Circulating Tumour Cells
Cell, is an initiator of the individuals ‘life with many hidden and unmasked facts and pathways which are cooperative with their contiguous environments. Moreover, Cancer Cells are characterized with the puzzling strategy which requires reinstatement in cancer research. So, bridging Cell Biology to Cancer is a leading channel to the translational research. In fact, the triangle of ‘Cancer/Cell/Biology’ consists of many layers of facts with cooperative functions. [..] READ MORE
TP53 Mutations and its Consequences: Insight into Leukemia and Lymphoma Cases
TP53 mutations are among the most common genetic alterations observed in human cancers and its product p53 has a major role in protection of the genome. In acute lymphoblastic leukemia (ALL), around 16.2% had normal karyotype by chromosome banding techniques, while 93% showed a TP53 mutation. Chromosome 17 showed monosomy in the majority of them. In chronic lymphoblastic leukemia (CLL), with median follow up of 8.1 years, 14.8% had TP53 mutations. Subclonal TP53 mutations were mostly missense [..] READ MORE
Infantile Hepatic Hemangioendothelioma, A Review of Literature
Despite its rarity, Infantile hepatic hemangioendothelioma (IHHE) is the most common hepatic vascular tumor in children [1]. According to the International Society for the Study of Vascular Anomalies (ISSVA) classification, lesions can be classified into focal, multifocal and diffuse [2]. While hepatomegaly is the most common presenting feature, IHHE may be accompanied by cardiovascular complications, [..] READ MORE
Cucurbitacin B Restored Cisplatin Sensitivity of Ovarian Cancer Cells by Altering Fatty Acid Synthase and LRP-130 Protein Expression
The first line in chemotherapy for ovarian cancer is platinum-based drugs. Despite combination treatment regimes, the 5-year survival rate still in decrease due to the resistance of the recurrent disease to the treatment. Finding a natural product that can restore cell’ sensitivity to the common therapeutic drugs is needed. Recent finding in our research showed that cucurbitacin B sensitizes the cisplatin-resistant ovarian cancer cell lines to the cytotoxicity of cisplatin. The aim of this work [..] READ MORE
Cancer Treatment with Pro and Antioxidant Agents
In almost all types of cancers mild to moderately elevated levels of reactive oxygen species (ROS) activates oncogenic signalling pathway which facilitates cancer initiation progression, invasion and metastasis. Extremely high level of ROS generated by conventional cancer [..] READ MORE
Thoracic Malignancies: Insights into Different Therapeutic and Technical Options
The World Health Organization (WHO) reports that cancer is the second leading cause of death globally [1]. Focusing on thoracic cancers, there are distinct epidemiological pictures. Among all tumors, lung cancer has the highest incidence and mortality when both genders are [..] READ MORE
Total Articles Published
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